Over deze opleiding
Medical epigenomics is the only Master's specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression.
The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As epigenetic modifications are reversible, you can imagine the great potential of so-called epi-drugs.
In this specialisation, you'll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing and analysing proteins by mass spectrometry. In addition, you'll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression.
The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As epigenetic modifications are reversible, you can imagine the great potential of so-called epi-drugs.
In this specialisation, you'll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing and analysing proteins by mass spectrometry. In addition, you'll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.
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Radboud Universiteit Nijmegen
Comeniuslaan 4
6525 HP Nijmegen
Hoge waardering
De Radboud Universiteit Nijmegen (RU) bevindt zich op het landgoed Heyendael. De universiteit telt samen met het Universitair Medisch Centrum St. Radboud tienduizend medewerkers en ruim 19.000 studenten. Als je gaat studeren aan de Radboud Universiteit, zul je merken dat...